Here, we describe a new and relatively rare subgroup of spinal ependymal tumors identified using DNA methylation profiling that is distinct from other molecular subgroups of ependymoma. However, their treatment can be challenging if infiltration of the spinal cord or dissemination throughout the central nervous system (CNS) occurs and, in these cases, clinical outcome remains poor. Spinal ependymal tumors form a histologically and molecularly heterogeneous group of tumors with generally good prognosis. ![]() MYCN amplification drives an aggressive form of spinal ependymoma
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